Adagene

DPL

Dynamic Precision Library (DPL) — computational biology-driven antibody discovery platform powering NEObody, SAFEbody, and POWERbody technologies for novel cancer immunotherapy development

NEObody

NEObody technology — antibody engineering platform targeting unique, evolutionarily conserved epitopes with species cross-reactivity; focus on oncology/immuno-oncology targets including CTLA-4 and CD137

SAFEbody · Sanofi

SAFEbody precision masking technology — proprietary platform that masks antibody binding sites for conditional activation in the tumor microenvironment, reducing on-target off-tumor toxicity; licensed to Sanofi and Exelixis for tumor targets

POWERbody

POWERbody technology — Fc-engineering and bispecific T-cell engager platform combining SAFEbody masking with enhanced effector function (IgG1 isotype and enhanced versions) for oncology; includes masked TCEs with co-stimulatory signals such as CD28

SAFEbody · Exelixis

Precision masking technology platform that shields the binding domain of antibody therapeutics, enabling tumor-specific targeting via activation in the tumor microenvironment while minimizing on-target off-tumor toxicity; applicable to Fc empowered antibodies, ADCs, and bi/multi-specific T-cell engagers; focus area: oncology

Dynamic Precision Library

Proprietary platform composed of NEObody, SAFEbody, and POWERbody technologies; computational biology and AI-driven antibody discovery platform for novel cancer immunotherapies

SAFEbody · Arc Bio

SAFEbody® — masked antibody platform technology enabling conditional activation of therapeutic antibodies, applied here to masked CD3 T cell engagers in oncology collaboration with Arc Bio

Targets: CD3

SAFEbody · Third Arc Bio

Precision masking technology that shields the binding domain of antibody therapeutics, enabling tumor microenvironment-activated, tumor-specific targeting while minimizing on-target off-tumor toxicity. Applicable to Fc empowered antibodies, ADCs, and bi/multi-specific T cell engagers including masked CD3 T cell engagers. Core component of the Dynamic Precision Library (DPL) platform.

Targets: CD3, CTLA-4

NEObody · Third Arc Bio

Antibody discovery platform component of Adagene's Dynamic Precision Library (DPL); used in conjunction with SAFEbody to generate novel masked antibody therapeutics including CD3 T cell engagers