Summit Therapeutics

SMMT Lead: NDA Submitted 16 Biotech Distilled articles ↓

Most recent annual filing: 2026-02-15

Catalyst timeline

ivonescimab NSCLC interim2H 2026ivonescimab NSCLC interim, 2H 2026, material
HARMONi-GU1 corporate update4Q 2026HARMONi-GU1 corporate update, 4Q 2026, routine
ivonescimab NSCLC PDUFA dateNov 14, 2026ivonescimab NSCLC PDUFA date, Nov 14, 2026, thesis-defining
ivonescimab NSCLC FDA decisionNov 14, 2026ivonescimab NSCLC FDA decision, Nov 14, 2026, thesis-defining
HARMONi-3 non-squamous readout1H 2027HARMONi-3 non-squamous readout, 1H 2027, notable

Bar width shows how precise the guidance is — a pin is a stated date, a wide band a six-month window. Deeper blue means more of the thesis rides on the event; it is not a view on the stock.

Pipeline (5 active programs)

ivonescimab

SMT112 · AK112

Protein Target: PD-1, VEGF-A, VEGF

Non-Small Cell Lung Cancer NDA Submitted Akeso NCT05899608
Colorectal Cancer Phase 3 Akeso NCT05382442
Urothelial Carcinoma Phase 2 NCT07815665
Cholangiocarcinoma Phase 3 HARMONi-GI1 trial Akeso NCT06529718

ivonescimab

SMT112

Protein Target: PD-1, VEGF-A, VEGF

Head and Neck Squamous Cell Carcinoma Phase 3 GSK NCT07094685

Discontinued (1)

ivonescimab — Clear Cell Renal Cell Carcinoma · not a Summit-sponsored program — Arcus conducts and sponsors the casdatifan+ivonescimab ccRCC cohort in its ARC-20 platform study; Summit only supplies drug and co-funds (collaborator, not sponsor)

Biotech Distilled coverage (16)

2026-09-16 UPDATE: Summit Therapeutics (SMMT) - The Western Confidence Interval Crosses One 🔒 Paid
2026-09-15 UPDATE: Summit Therapeutics (SMMT) - The Hazard Ratio Arrives 🔒 Paid
2026-09-02 UPDATE: Summit Therapeutics (SMMT) - Keytruda Just Lost a Head-to-Head on Survival 🔒 Paid
2026-08-25 UPDATE: Summit Therapeutics (SMMT) - The Drug Escapes the Lung 🔒 Paid
2026-08-13 UPDATE: Summit Therapeutics (SMMT) - China Says Yes, Round Three 🔒 Paid
2026-07-23 UPDATE: Summit Therapeutics (SMMT) - The Form 4s Landed 🔒 Paid
2026-07-22 UPDATE: Summit Therapeutics (SMMT) - The Western OS Number Just Caught Up 🔒 Paid
2026-06-11 UPDATE: Summit Therapeutics (SMMT) - The Deal Got Pulled
2026-06-09 UPDATE: Summit Therapeutics (SMMT) - The $500M Bait-and-Switch
2026-06-03 UPDATE: Summit Therapeutics (SMMT) - The Insiders Got the Green Light
2026-06-02 UPDATE: Summit Therapeutics (SMMT) - The Plenary Delivered. The Tape Didn’t. 🔒 Paid
2026-05-02 UPDATE: Summit Therapeutics (SMMT) - The 25% Panic Into ASCO 🔒 Paid
2026-05-01 UPDATE: Summit Therapeutics (SMMT) - Q1 2026 Earnings, an iDMC Pass, and an ASCO Plenary Slot 🔒 Paid
2026-03-29 UPDATE: Summit Therapeutics (SMMT) - ELCC 2026 Data 🔒 Paid
2026-03-01 UPDATE: Summit Therapeutics (SMMT) - EoY 2025 Update 🔒 Paid
2026-02-20 Summit Therapeutics (SMMT): Scientific Deep Dive for Ivonescimab and Pipeline Products 🔒 Paid

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